Adenomyosis is a benign condition in which tissue from the endometrial layer, or the innermost layer of

the uterus, grows into a layer of muscle in the uterus. The uterus is a muscular organ with three layers:

the endometrium (inner lining), the myometrium (middle muscular layer) and serosa (outer smooth

layer that covers the uterus) [1]. When the endometrial tissue grows into the muscle, it causes the

uterus to enlarge. It is unknown what causes this condition; however, the most likely theory is that small

areas of trauma and inflammation in the myometrium causes the endometrium to grow into the

muscular layer [2]. Adenomyosis can cause painful and distressing symptoms; however, it is a benign

condition that does not cause or increase the risk of cancer [2].


Painful periods can be caused by several medical conditions, and adenomyosis often will present by

patients complaining of painful menstruation; however, some patients who have adenomyosis may not

experience any symptoms at all. The most common symptoms of adenomyosis are usually painful

and/or heavy bleeding during periods, chronic pelvic pain and irregular bleeding from the uterus.

Abnormal uterine bleeding is when bleeding from the uterus happens at irregular times (not associated

with periods) or there is bleeding for prolonged periods of time. Infertility may occur; however, the

association is still unclear [4].


The first step of diagnosing adenomyosis is to collect information on symptoms as well as past

medical and surgical history. When a physician examines the uterus by gently palpating the pelvic area,

the uterus typically feels soft and is symmetrical. Irregularities on the exam may include an abnormally

large uterus, firmness, a palpable mass or even tenderness felt by the patient during the exam. If

adenomyosis is suspected, a transvaginal ultrasound is then recommended to evaluate and diagnose



There are multiple treatment options to help with symptoms. Nonsteroidal anti-inflammatory drugs

(NSAIDS) can help improve pain and inflammation, and these include common over-the-counter

medications such as ibuprofen. Other medication options include hormone therapy or oral

contraceptives. Specific hormones can decrease estrogen in the body, which is important since estrogen

causes the endometrial layer to grow. These medications can limit the overgrowth of the endometrial

layer of the uterus. The combined oral contraceptive pill is a combination of progestin and estrogen

which works by decreasing ovulation and estrogen production within the body, working similarly to

decrease endometrial growth [5].


Surgical treatment can include a hysterectomy, or removal of the uterus, which is usually

done in patients with severe symptoms or in patients who do not wish to become pregnant.

Another method, known as uterine artery embolization, uses a procedure to block

uterine blood vessels in order to stop blood flow to this area. This will cause the tissue to die and

prevent it from overgrowing. In patients who desire future pregnancy, it is possible to remove either the

focal adenomyosis or diffuse area around the uterine wall [3] while still keeping the uterus intact.


Fibroids, also known as uterine leiomyomas, are very common benign growths of smooth muscle cells of

the muscular layer of the uterus (myometrium). Between 40% and 60% of women can develop fibroids,

though only 20% to 50% of patients with fibroids have symptoms [2,6]. Symptoms are similar to

adenomyosis, with the most common being heavy or abnormal bleeding. Infertility is possible but rare

(about 1% to 3% of infertility cases are due to fibroids) [5]. On pelvic exam, the uterus will be enlarged in

various locations and small, smooth masses can be felt. This is different from adenomyosis, where the

entire uterus is enlarged. After an exam by your physician, fibroids are confirmed by a diagnostic

Related: Is My Vagina Normal? Plus A Female Anatomy Chart

transvaginal ultrasound. Treatment is similar to the treatment of adenomyosis with hormonal options.

For women desiring future pregnancy, myomectomies (surgical removal of the fibroid only, while

keeping the uterus intact) can be performed.


Endometriosis is a condition in which the inner lining (endometrium) grows outside the uterus, as

opposed to adenomyosis where the endometrium grows into the muscular layer in the uterus only and

does not extend past this area. Tissue can grow on fallopian tubes, ovaries, bowel, appendix, bladder

and other structures. It can cause painful periods, pain during intercourse, uncomfortable bowel

movements and even infertility. Infertility is more common with endometriosis than with fibroids or

adenomyosis. Pelvic examination by a physician may demonstrate tenderness in the pelvic region, pain

with movement of the uterus, or even an immobile uterus. However, many patients may not have any

abnormal findings. Diagnosis is usually made with laparoscopy, a procedure where a small camera is

placed inside the abdomen to look for endometrial tissue at internal structures such as the uterus,

fallopian tubes, ovaries and bowel. Treatment is similar to adenomyosis with anti-inflammatory

medication to help with pain and hormonal methods to suppress tissue growth. Surgical treatment

includes removing or destroying the abnormal tissue. As with adenomyosis, if a patient does not desire

to have future pregnancy or has severe symptoms, surgery to remove the uterus, fallopian tubes, and

ovaries may be performed [2,5,7].


Adenomyosis, uterine fibroids and endometriosis are common conditions that can cause no symptoms

at all or become severe enough to cause significant pain and distress. This can depend on various factors

such as age, ethnicity and location/extent of the abnormal tissue. While moderate to severe symptoms

can be concerning for patients, they are typically benign conditions. However, there are several medical

and surgical treatment options available to help with these conditions. If you think you are experiencing

symptoms of adenomyosis, please consult your physician for a treatment plan that is right for you.



1. Anatomy of the uterus. (n.d.). Retrieved March 26, 2021, from


2. Dougherty M.P., & DeCherney A.H. (2019). Benign disorders of the uterine

corpus. DeCherney A.H., & Nathan L, & Laufer N, & Roman A.S.(Eds.), CURRENT

Diagnosis & Treatment: Obstetrics & Gynecology, 12e. McGraw-

Hill. https://accessmedicine-mhmedical-

3. Stewart, Elizabeth et al. (2021). Uterine adenomyosis. UpToDate. Accessed on March 26,


4. Harada, T., Khine, Y. M., Kaponis, A., Nikellis, T., Decavalas, G., & Taniguchi, F. (2016).

The Impact of Adenomyosis on Women's Fertility. Obstetrical & gynecological

survey, 71(9), 557–568.

5. Benign uterine pathology. Hoffman B.L., & Schorge J.O., & Halvorson L.M., & Hamid


& Corton M.M., & Schaffer J.I.(Eds.), (2020). Williams Gynecology, 4e. McGraw-

Hill. https://accessmedicine-mhmedical-

6. Stewart, Elizabeth et al (2021). Uterine fibroids (leiomyomas): Epidemiology, clinical

features, diagnosis, and natural history. UpToDate. Accessed on March 26, 2021.

7. Schenken, Robert, Barbieri, Robert, Eckler, Kristen (2021). UpToDate: Endometriosis:

pathogenesis, clinical features, and diagnosis. UpToDate. Accessed on March 26, 2021.

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